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2016 MS Defenses




Masters Candidate Michael D. Hunckler - "Investigation of a Rabbit Ulnar Loading Model for Atypical Fractures in Cortical Bone During Long-Term Bisphosphonate Treatment"

WHERE: 103 Multidisciplinary Research Building
FROM: 10:00AM TO 11:30AM

Bisphosphonates are the most common pharmaceutical used to reduce fracture risk in postmenopausal women suffering from osteoporosis, but long-term bisphosphonate treatment has been associated with a rare adverse effect, atypical femoral fractures (AFFs). There is currently no suitable animal model to study the underlying pathophysiological mechanisms of AFFs, which remain unknown. Therefore, the objective of this project was to investigate a rabbit ulnar loading model for AFFs in cortical bone during long-term bisphosphonate treatment.

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