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Philippe Sucosky

Assistant Professor

Education: Postdoc - Georgia Institute of Technology, 2008; Ph.D. - Georgia Institute of Technology, 2005; M.S. - Georgia Institute of Technology, 2000

Research Interests: Cardiovascular bioengineering, biofluid mechanics, mechanobiology, biomedical device design

Courses: Fluid Mechanics; Cardiovascular Biofluid Mechanics

Email: philippe.sucosky@nd.edu

Phone: 574.631.1898

Office: 143 Multidisciplinary Research Building

Website: www.nd.edu/~psucosky

Dr. Sucosky directs the Multi-Scale Cardiovascular Bioengineering Laboratory (MSCBL) hosted in the Multidisciplinary Research Building. The MSCBL applies state-of-the-art engineering techniques to solve challenges in the cardiovascular field and to improve human health. Specific problems currently studied by Dr. Sucosky include the computational and experimental characterizations of heart valve hemodynamics, the elucidation of the mechnobiological pathways leading to aortic valve calcification, and the exploration and modeling of the relationships between blood flow and heart valve disease. In this highly interactive research program, the knowledge of the flow characteristics in different cardiovascular disorder configurations, and the identification and prediction of the mechanobiological pathways leading to those disorders will guide the development of early medical interventions for the treatment of pathological and congenital cardiovascular conditions.

Selected Publications

  • Sucosky P. Flow Transport Phenomena in Tissue Engineering: Flow Characterization and Modeling of Cartilage Development in a Spinner-Flask Bioreactor. ISBN 9783639162264, VDM Verlag Dr. Mller; June 2009.
  • Dasi LP, Sucosky P, de Zelicourt D, Sundareswaran K, Jimenez J, Yoganathan AP. Advances in cardiovascular fluid mechanics: bench to bedside. Ann N Y Acad Sci. 2009; 1161: 1-25. http://dx.doi.org/10.1111/j.1749-6632.2008.04320.x
  • Balachandran K, Sucosky P, Jo H, Yoganathan AP. Elevated Cyclic Stretch Alters Matrix Remodeling in Aortic Valve Cusps - Implications for Degenerative Aortic Valve Disease? Am J Physiol Heart Circ Physiol. 2009; 296: H756-64. http://dx.doi.org/10.1152/ajpheart.00900.2008
  • Sucosky P, Elhammali A, Balachandran K, Jo H, Yoganathan AP. Altered Shear Stress Stimulates Upregulation of Endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-?1-Dependent Pathway. Arterioscler Thromb Vasc Biol. 2009; 29: 254-260. http://dx.doi.org/10.1161/ATVBAHA.108.176347
  • Sucosky P, Dasi LP, Paden ML, Fortenberry JD, Yoganathan AP. Assessment of Current Continuous Hemofiltration Systems and Development of a Novel Accurate Fluid Management System for Use in Extracorporeal Membrane Oxygenation. J. Med. Devices. 2008; 2: 035002-1-035002-8. http://dx.doi.org/10.1115/1.2952818
  • Sucosky P, Padala M, Elhammali A, Balachandran K, Jo H, Yoganathan AP. Design of an Ex Vivo Culture System to Investigate the Effects of Shear Stress on Cardiovascular Tissue. J Biomech Eng. 2008; 130: 035001-035008. http://dx.doi.org/10.1115/1.2907753
  • Sucosky P, Osorio DF, Brown JB, Neitzel GP. The fluid mechanics of a spinner-flask bioreactor. Biotechnol Bioeng 2004; 85: 34-46. http://dx.doi.org/10.1002/bit.10788
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