Home > Research > Electromechanical Signal Transduction in Engineered Tissues

Electromechanical Signal Transduction in Engineered Tissues

Aim of this project is to study the electrical and mechanical interactions of the cardiac tissue cells using micropatterned cardiac cell co-cultures.

The cardiac cells have unique capability to respond directly to mechanical forces, such as stretch and shear, by eliciting excitatory response by the aid of membrane bound stretch activated ion channels which results in generation of action potentials known as mechano-electric feedback that then propagates across the entire tissue or organ. Impairment in conduction is usually caused due to development of scar tissues that have mechanically distinct properties than the native cells. Understanding and modulating the cardiac cell responses at cellular scale would be important for bioengineering applications ranging from the treatment of heart diseases to biorobotics.

Electromechanical Signal Transduction in Engineered Tissues