Category: Research and Innovation

Yanliang Zhang

Notre Dame Engineering and Harvard Medical School collaborate on 4-year NIH project to create lab-grown organs

While scientists have successfully printed small patches of human tissue, scaling those tissues into full-sized organs has remained elusive. In natural organisms, every cell must be within roughly 100 to 200 micrometers—about the thickness of two human hairs—of a blood vessel to receive oxygen …

A pipette places drops of green liquid onto a microscope slide containing a small device

Heart-on-a-chip device identifies youth-enhancing “cocktail” to repair old hearts

The heart is a pump that wears out over time—that, at least, was the prevailing view. New research has shown that the heart’s aging results from changes in intercellular communications, which tell heart cells, sometimes even healthy ones, to stiffen and break down. By decoding these complex …

Katharine White and Donny Hanjaya-Putra

Notre Dame researchers uncover the molecular driving force behind hallmark of aggressive, metastatic cancers

To invade healthy tissues and continue growing, aggressive cancers mimic and circumvent the body’s native piping system of veins and arteries. Through this process, known as vasculogenic mimicry (VM), tumor cells form fluid-conducting channels that transport blood, oxygen, and nutrients directly …

A young woman looks at a microscope slide that has a dab of clear gel in the middle of it

3D-bioprinted model offers new way to study and treat obesity-related heart disease

Heart disease is the leading cause of death among people with obesity, a condition affecting one in eight people worldwide. Studies show that fat around the heart can fuel inflammation, damage heart muscle cells, disrupt heart rhythm and increase the risk of heart failure, but the precise …

Two researchers in white lab coats and safety glasses work in a lab. A man in blue gloves uses a tool to transfer liquid into a small container near a multi-well plate with reddish liquid. A woman observes him, smiling softly.

Physical pressure on the brain triggers neurons’ self-destruction programming

To think, feel, talk and move, neurons send messages through electrical signals in the brain and spinal cord. This intricate communication network is built of billions of neurons connected by synapses and managed and modified by glial cells. When neurons die, this communication network is …

Two blue, gloved hands hold the superblack material

Robust, low-cost superblack material leverages fundamental geometry and engineering methods

Cave entrances often appear black and forbidding.  Light enters, but little escapes, absorbed as it “bounces around” the interior. To trap light in much the same way, engineers at the University of Notre Dame have devised a superblack material from a matrix of microscopic, …

A machine to detect certain molecules in air samples. The machine consists of a glass box connected with various wires, with a green air pump on one side.

Airborne disease detection made easier with new, low-cost device

Airborne hazardous chemicals can be dilute, mobile, and hard to trap. Yet accurately measuring these chemicals is critical in protecting human health and the environment.  Now, a new, small, low-cost device, nicknamed ABLE, could make the collection and detection of airborne hazards much …

The Golden Dome framed by green trees

Notre Dame announces 2025 Strategic Framework Grant recipients

The University of Notre Dame has announced the awardees of its 2025 Strategic Framework Grant (SFG) Program. Launched in 2024, the program is an internal funding opportunity that stimulates engagement with the priorities outlined in Notre Dame 2033: A Strategic Framework. The program, sponsored …

A welder wearing a protective mask and camouflage pants works on a metal container, surrounded by bright sparks and smoke.

Federally funded research explores how AI tools can improve manufacturing worker safety, product quality

Recent artificial intelligence advances have largely focused on text, but AI increasingly shows promise in other contexts, including manufacturing and the service industry. In these sectors, targeted AI improvements can improve product quality and worker safety, according to a new study …

a pile of gold athletic helmets lays on the sidewalk in front of the Golden Dome

Notre Dame Research, Athletics address challenges of ACL tears, sleep loss, and stress in new joint research projects

Notre Dame Research and Athletics have awarded three research teams the first-ever Human Performance & Wellness Research Grants. The grants will provide funding to support exceptional research projects that contribute meaningfully to fields related to the health, well-being, and performance of …